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Target
Bombesin receptor subtype-3
Ligand
BDBM50447476
Substrate
n/a
Meas. Tech.
ChEMBL_1288543 (CHEMBL3118976)
EC50
62±n/a nM
Citation
 Matsufuji, T; Shimada, K; Kobayashi, S; Kawamura, A; Fujimoto, T; Arita, T; Hara, T; Konishi, M; Abe-Ohya, R; Izumi, M; Sogawa, Y; Nagai, Y; Yoshida, K; Takahashi, H Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration. Bioorg Med Chem Lett 24:750-5 (2014) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS3_MOUSE | Brs3
Type:
PROTEIN
Mol. Mass.:
44239.49
Organism:
Mus musculus
Description:
ChEMBL_1445902
Residue:
399
Sequence:
MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
  
Inhibitor
Name:
BDBM50447476
Synonyms:
CHEMBL3115389
Type:
Small organic molecule
Emp. Form.:
C23H26F3N3O4
Mol. Mass.:
465.4654
SMILES:
CC(C)COc1cccc(CC(=O)N2CCNc3nc(ccc3[C@H]2CC(O)=O)C(F)(F)F)c1 |r|
Structure:
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