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Target
Cholesteryl ester transfer protein
Ligand
BDBM50447559
Substrate
n/a
Meas. Tech.
ChEMBL_1289410 (CHEMBL3116906)
IC50
>32000±n/a nM
Citation
 Wang, Y; Yang, W; Finlay, HJ; Harikrishnan, LS; Jiang, J; Kamau, MG; Van Kirk, K; Nirschl, DS; Taylor, DS; Chen, AY; Yin, X; Sleph, PG; Yang, RZ; Huang, CS; Adam, LP; Lawrence, RM; Wexler, RR; Salvati, ME Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett 24:860-4 (2014) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50447559
Synonyms:
CHEMBL3116358
Type:
Small organic molecule
Emp. Form.:
C28H20ClF4N5
Mol. Mass.:
537.939
SMILES:
Fc1cc(cc(c1)C(Cc1ccccc1)(Nc1nnc([nH]1)-c1ccccc1)c1ccc(Cl)cn1)C(F)(F)F
Structure:
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