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Target
Protein-arginine deiminase type-2
Ligand
BDBM50447757
Substrate
n/a
Meas. Tech.
ChEMBL_1290370 (CHEMBL3119085)
Ki
8080±n/a nM
Citation
 Dreyton, CJ; Anderson, ED; Subramanian, V; Boger, DL; Thompson, PR Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem 22:1362-9 (2014) [PubMed]  Article 
Target
Name:
Protein-arginine deiminase type-2
Synonyms:
KIAA0994 | PAD-H19 | PAD2 | PADI2 | PADI2_HUMAN | PDI2 | Peptidylarginine deiminase II | Protein-arginine deiminase type II
Type:
PROTEIN
Mol. Mass.:
75552.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1290379
Residue:
665
Sequence:
MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP
  
Inhibitor
Name:
BDBM50447757
Synonyms:
CHEMBL57818
Type:
Small organic molecule
Emp. Form.:
C14H9N3O2
Mol. Mass.:
251.2402
SMILES:
NC1=CC(=O)c2ccc(nc2C1=O)-c1ccccn1 |t:1|
Structure:
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