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TargetHistone-lysine N-methyltransferase Su(var)3-9
LigandBDBM50315537
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1294298
IC50 600±n/a nM
Citation Cherblanc, FLChapman, KLReid, JBorg, AJSundriyal, SAlcazar-Fuoli, LBignell, EDemetriades, MSchofield, CJDiMaggio, PABrown, RFuchter, MJ On the histone lysine methyltransferase activity of fungal metabolite chaetocin. J Med Chem56:8616-25 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase Su(var)3-9
Name:Histone-lysine N-methyltransferase Su(var)3-9
Synonyms:H3-K9-HMTase | Histone H3-K9 methyltransferase | KMT1 | Lysine N-methyltransferase 1 | Protein suppressor of variegation 3-9 | Su(var)3-9
Type:PROTEIN
Mol. Mass.:71919.98
Organism:Drosophila melanogaster
Description:ChEMBL_1294298
Residue:635
Sequence:
MATAEAQIGVNRNLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAI
SGVQTVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSR
FRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSLN
GFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKW
LGYHDSENTWESLANVADCAEMEKFVERHQQLYETYIAKITTELEKQLEALPLMENITVA
EVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLAL
FEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEE
CTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLV
LFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTA
QDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSF
DYIRADNEDVPYENLSTAVRVECRCGRDNCRKVLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50315537
NameBDBM50315537
Synonyms:CHEMBL1089316 | chaetocin
TypeSmall organic molecule
Emp. Form.C30H28N6O6S4
Mol. Mass.696.84
SMILESCN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21 |r,THB:36:35:31.33:26.27,7:15:1.2:22.21,38:37:31.33:26.27,17:16:1.2:22.21|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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