Target
Glucokinase regulatory protein
Ligand
BDBM50447286
Substrate
n/a
Meas. Tech.
ChEMBL_1296099 (CHEMBL3131528)
IC50
1420±n/a nM
Citation
 Ashton, KSAndrews, KLBryan, MCBryan, MCChen, JChen, KChen, MChmait, SCroghan, MCupples, RFotsch, CHelmering, JJordan, SRKurzeja, RJMichelsen, KPennington, LDPoon, SFSivits, GVan, GVonderfecht, SLWahl, RCZhang, JLloyd, DJHale, CSt Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept. J Med Chem 57:309-24 (2014) [PubMed]  Article 
Target
Name:
Glucokinase regulatory protein
Synonyms:
GCKR | GCKR_HUMAN | GKRP | Glucokinase regulator
Type:
PROTEIN
Mol. Mass.:
68685.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103091
Residue:
625
Sequence:
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ
  
Inhibitor
Name:
BDBM50447286
Synonyms:
CHEMBL3113992
Type:
Small organic molecule
Emp. Form.:
C17H16F6N2O3S2
Mol. Mass.:
474.441
SMILES:
OC(c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1cccs1)(C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: