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Target
DNA nucleotidylexotransferase
Ligand
BDBM50448691
Substrate
n/a
Meas. Tech.
ChEMBL_1297318 (CHEMBL3132283)
IC50
>200000±n/a nM
Citation
 Mizushina, Y; Suzuki-Fukudome, H; Takeuchi, T; Takemoto, K; Kuriyama, I; Yoshida, H; Kamisuki, S; Sugawara, F Formosusin A, a novel specific inhibitor of mammalian DNA polymeraseß from the fungus Paecilomyces formosus. Bioorg Med Chem 22:1070-6 (2014) [PubMed]  Article 
Target
Name:
DNA nucleotidylexotransferase
Synonyms:
DNTT | TDT | TDT_BOVIN
Type:
PROTEIN
Mol. Mass.:
58304.95
Organism:
Bos taurus
Description:
ChEMBL_1297318
Residue:
509
Sequence:
MDPLCTASSGPRKKRPRQVGASMASPPHDIKFQNLVLFILEKKMGTTRRNFLMELARRKGFRVENELSDSVTHIVAENNSGSEVLEWLQVQNIRASSQLELLDVSWLIESMGAGKPVEITGKHQLVVRTDYSATPNPGFQKTPPLAVKKISQYACQRKTTLNNYNHIFTDAFEILAENSEFKENEVSYVTFMRAASVLKSLPFTIISMKDTEGIPCLGDKVKCIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRSLSKIMSDKTLKFTKMQKAGFLYYEDLVSCVTRAEAEAVGVLVKEAVWAFLPDAFVTMTGGFRRGKKIGHDVDFLITSPGSAEDEEQLLPKVINLWEKKGLLLYYDLVESTFEKFKLPSRQVDTLDHFQKCFLILKLHHQRVDSSKSNQQEGKTWKAIRVDLVMCPYENRAFALLGWTGSRQFERDIRRYATHERKMMLDNHALYDKTKRVFLKAESEEEIFAHLGLDYIEPWERNA
  
Inhibitor
Name:
BDBM50448691
Synonyms:
CHEMBL3127729
Type:
Small organic molecule
Emp. Form.:
C17H25NO3
Mol. Mass.:
291.3853
SMILES:
C\C(\C=C\CCC(=O)N1CCCC1=O)=C/C1CCCCO1
Structure:
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