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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50448704
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1297897
IC50 0.450000±n/a nM
Citation Goldberg, FWDossetter, AGScott, JSRobb, GRBoyd, SGroombridge, SDKemmitt, PDSjögren, TGutierrez, PMdeSchoolmeester, JSwales, JGTurnbull, AVWild, MJ Optimization of brain penetrant 11-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. J Med Chem57:970-86 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1)
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM50448704
NameBDBM50448704
Synonyms:CHEMBL3127856
TypeSmall organic molecule
Emp. Form.C22H32N2O5S
Mol. Mass.436.565
SMILESCOC[C@H](C)Oc1nc([C@H]2CCCO2)c(s1)C(=O)NC1C2CC3CC1CC(O)(C3)C2 |r,wU:3.3,wD:9.8,TLB:18:19:23:25.26.28,29:26:19.20.21:23,THB:29:20:23:25.26.28,28:26:19:21.22.23,28:22:19:25.29.26,27:26:19:21.22.23,27:26:19.20.21:23,(31.36,-30.47,;32.82,-30.97,;33.98,-29.96,;35.44,-30.46,;35.73,-31.97,;36.6,-29.45,;38.06,-29.95,;38.51,-31.42,;40.05,-31.44,;40.93,-32.7,;40.44,-34.15,;41.67,-35.08,;42.93,-34.19,;42.48,-32.72,;40.55,-29.98,;39.32,-29.06,;41.88,-29.21,;41.87,-27.67,;43.21,-29.97,;44.54,-29.2,;46.04,-28.81,;46.07,-27.22,;47.13,-26.01,;45.78,-26.46,;45.76,-27.95,;47.08,-28.46,;48.48,-28.14,;50.02,-28.1,;48.52,-26.61,;47.45,-29.4,)|
Structure
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