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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50448706
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1297897
IC50 0.400000±n/a nM
Citation Goldberg, FWDossetter, AGScott, JSRobb, GRBoyd, SGroombridge, SDKemmitt, PDSjögren, TGutierrez, PMdeSchoolmeester, JSwales, JGTurnbull, AVWild, MJ Optimization of brain penetrant 11-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. J Med Chem57:970-86 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1)
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50448706
NameBDBM50448706
Synonyms:CHEMBL3127854
TypeSmall organic molecule
Emp. Form.C19H26N2O4S
Mol. Mass.378.486
SMILESCOc1nc([C@H]2CCCO2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:22.25,wD:15.16,5.4,TLB:14:15:19:21.22.24,25:22:15.16.17:19,THB:25:16:19:21.22.24,24:22:15:17.18.19,24:18:15:21.25.22,23:22:15:17.18.19,23:22:15.16.17:19,(.87,-30.81,;2.03,-29.8,;3.48,-30.3,;3.94,-31.77,;5.48,-31.79,;6.36,-33.05,;5.87,-34.5,;7.1,-35.43,;8.36,-34.54,;7.91,-33.07,;5.97,-30.33,;4.74,-29.41,;7.31,-29.56,;7.3,-28.02,;8.64,-30.32,;9.97,-29.55,;11.47,-29.16,;11.5,-27.57,;12.56,-26.36,;11.2,-26.81,;11.19,-28.3,;12.5,-28.81,;13.91,-28.49,;15.45,-28.45,;13.95,-26.96,;12.87,-29.75,)|
Structure
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