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Target
Proteasome subunit beta type-1
Ligand
BDBM50449237
Substrate
n/a
Meas. Tech.
ChEMBL_1294521 (CHEMBL3129429)
IC50
600±n/a nM
Citation
 Hovhannisyan, A; Pham, TH; Bouvier, D; Piroyan, A; Dufau, L; Qin, L; Cheng, Y; Melikyan, G; Reboud-Ravaux, M; Bouvier-Durand, M New C(4)- and C(1)-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform. Bioorg Med Chem Lett 24:1571-80 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50449237
Synonyms:
CHEMBL3128141
Type:
Small organic molecule
Emp. Form.:
C16H16N2O2
Mol. Mass.:
268.3104
SMILES:
CC1(C)OC(=O)c2c1ccnc2NCc1ccccc1
Structure:
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