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Target
Histone deacetylase
Ligand
BDBM50002747
Substrate
n/a
Meas. Tech.
ChEMBL_422128 (CHEMBL908249)
IC50
11.3±n/a nM
Citation
 Mai, A; Rotili, D; Massa, S; Brosch, G; Simonetti, G; Passariello, C; Palamara, AT Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans. Bioorg Med Chem Lett 17:1221-5 (2007) [PubMed]  Article 
Target
Name:
Histone deacetylase
Synonyms:
Histone deacetylase HD1B
Type:
PROTEIN
Mol. Mass.:
50930.01
Organism:
Zea mays
Description:
ChEMBL_422128
Residue:
458
Sequence:
MAASGEGVSLPSPAGGEDAHRRRVSYFYEPSIGDYYYGQGHPMKPHRIRMAHSLVVHYGLHRLLELSRPYPASEADIRRFHSDDYVAFLASATGNPGVLDPRAIKRFNVGEDCPVFDGLFPFCQASAGGSIGAAVKLNRGDADITVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKFHRRVLYVDIDVHHGDGVEEAFFTTNRVMTVSFHKYGDFFPGTGHITDVGAAEGKHYALNVPLSDGIDDTTFRGLFQCIIKKVMEVYQPDVVVLQCGADSLAGDRLGCFNLSVKGHADCLRFLRSYNVPMMVLGGGGYTIRNVARCWCYETAVAVGVEPDNKLPYNDYYEYFGPDYTLHIQPKSVENLNTTKDLENIKNMILENLSKIEHVPSTQFHDRPSDPEAPEEKEEDMDKRPPQRSRLWSGGAYDSDTEDPDSLKSEGKDVTANFQMKDEPKDDL
  
Inhibitor
Name:
BDBM50002747
Synonyms:
CHEMBL217546
Type:
Small organic molecule
Emp. Form.:
C15H16ClN3O3S
Mol. Mass.:
353.824
SMILES:
ONC(=O)CCCCSc1nc(cc(=O)[nH]1)-c1ccc(Cl)cc1
Structure:
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