Reaction Details Report a problem with these data
Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50003682
Substrate
n/a
Meas. Tech.
ChEMBL_500704 (CHEMBL966920)
IC50
23800±n/a nM
Citation
 Sunduru, N; Srivastava, K; Rajakumar, S; Puri, SK; Saxena, JK; Chauhan, PM Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials. Bioorg Med Chem Lett 19:2570-3 (2009) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50003682
Synonyms:
CHEMBL512253
Type:
Small organic molecule
Emp. Form.:
C18H19ClN4O2S
Mol. Mass.:
390.887
SMILES:
CCCCN1C(=O)C(=O)N(CCNc2ccnc3cc(Cl)ccc23)C1=S
Structure:
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