Target
Translocator protein
Ligand
BDBM50005294
Substrate
n/a
Meas. Tech.
ChEMBL_1295421 (CHEMBL3131058)
Ki
0.74±n/a nM
Citation
 Médran-Navarrete, VDamont, APeyronneau, MAKuhnast, BBernards, NPottier, GMarguet, FPuech, FBoisgard, RDollé, F Preparation and evaluation of novel pyrazolo[1,5-a]pyrimidine acetamides, closely related to DPA-714, as potent ligands for imaging the TSPO 18kDa with PET. Bioorg Med Chem Lett 24:1550-6 (2014) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50005294
Synonyms:
CHEMBL3125362
Type:
Small organic molecule
Emp. Form.:
C24H27FN4O
Mol. Mass.:
406.4958
SMILES:
CCN(CC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(cc1)C#CCCF
Structure:
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