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Target
Histone-lysine N-methyltransferase SETD7
Ligand
BDBM50001750
Substrate
n/a
Meas. Tech.
ChEMBL_1337749 (CHEMBL3240198)
IC50
9930±n/a nM
Citation
 Kashyap, S; Sandler, J; Peters, U; Martinez, EJ; Kapoor, TM Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors. Bioorg Med Chem 22:2253-60 (2014) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SETD7
Synonyms:
Histone-lysine N-methyltransferase SETD7 | KIAA1717 | KMT7 | SET domain-containing protein 7/9 (Set7/9) | SET7 | SET9 | SETD7 | SETD7_HUMAN
Type:
Enzyme
Mol. Mass.:
40691.12
Organism:
Homo sapiens (Human)
Description:
Q8WTS6
Residue:
366
Sequence:
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
  
Inhibitor
Name:
BDBM50001750
Synonyms:
CHEMBL3238424
Type:
Small organic molecule
Emp. Form.:
C29H21F3N2O2
Mol. Mass.:
486.4844
SMILES:
OC(=O)c1cccc(NCc2cccc(c2)-n2ccc3c(cccc23)-c2ccc(cc2)C(F)(F)F)c1
Structure:
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