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Target
Histamine H1 receptor
Ligand
BDBM50001751
Substrate
n/a
Meas. Tech.
ChEMBL_1338137 (CHEMBL3242004)
Ki
29512±n/a nM
Citation
 Sadek, B; Schwed, JS; Subramanian, D; Weizel, L; Walter, M; Adem, A; Stark, H Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties. Eur J Med Chem 77:269-79 (2014) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50001751
Synonyms:
CHEMBL3238444
Type:
Small organic molecule
Emp. Form.:
C18H26N4O
Mol. Mass.:
314.4252
SMILES:
Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1
Structure:
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