Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetEBifunctional epoxide hydrolase 2
LigandBDBM50002341
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1338955
IC50 49000±n/a nM
Citation Amano, YYamaguchi, TTanabe, E Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg Med Chem22:2427-34 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
EBifunctional epoxide hydrolase 2
Name:EBifunctional epoxide hydrolase 2
Synonyms:Cytosolic epoxide hydrolase 2 | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:Enzyme
Mol. Mass.:62613.07
Organism:Homo sapiens (Human)
Description:P34913
Residue:555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50002341
NameBDBM50002341
Synonyms:CHEMBL442384
TypeSmall organic molecule
Emp. Form.C8H5F3N2S
Mol. Mass.218.199
SMILESNc1nc2ccc(cc2s1)C(F)(F)F
Structure
n/a