Reaction Details Report a problem with these data
Target
Vascular endothelial growth factor A
Ligand
BDBM50002918
Substrate
n/a
Meas. Tech.
ChEMBL_1339790 (CHEMBL3243495)
IC50
0.320000±n/a nM
Citation
 Chen, QY; Liu, Y; Cai, W; Luesch, H Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity. J Med Chem 57:3011-29 (2014) [PubMed]  Article 
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
232
Sequence:
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM50002918
Synonyms:
Apratoxin S4
Type:
Small organic molecule
Emp. Form.:
C44H69N5O8S
Mol. Mass.:
828.112
SMILES:
[H][C@]12CSC(=N1)[C@@H](C)[C@@H](O)C[C@H](C)C[C@H](OC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])([C@@H](C)CC)N(C)C(=O)[C@H](C)N(C)C(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC2)C(C)(C)C |r,c:4|
Structure:
Search PDB for entries with ligand similarity: