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Target
Aurora kinase B
Ligand
BDBM31093
Substrate
n/a
Meas. Tech.
ChEMBL_1339463 (CHEMBL3243856)
IC50
172±n/a nM
Citation
 Luo, Y; Deng, YQ; Wang, J; Long, ZJ; Tu, ZC; Peng, W; Zhang, JQ; Liu, Q; Lu, G Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors. Eur J Med Chem 78:65-71 (2014) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AURKB_MOUSE | Aik2 | Aim1 | Airk2 | Ark2 | Aurkb | Serine/threonine-protein kinase 12 | Stk1 | Stk12 | Stk5
Type:
PROTEIN
Mol. Mass.:
39401.97
Organism:
Mus musculus
Description:
ChEMBL_1339463
Residue:
345
Sequence:
MAQKENAYPWPYGSKTSQSGLNTLSQRVLRKEPATTSALALVNRFNSQSTAAPGQKLAENKSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVDLKFPSSVPSGAQDLISKLLKHNPWQRLPLAEVAAHPWVRANSRRVLPPSAL
  
Inhibitor
Name:
BDBM31093
Synonyms:
4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | BDBM31832 | CHEMBL259084 | MLN-8054 | cid_11712649
Type:
Small organic molecule
Emp. Form.:
C25H15ClF2N4O2
Mol. Mass.:
476.862
SMILES:
OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 |c:13|
Structure:
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