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Target
Proteasome subunit beta type-7
Ligand
BDBM50007197
Substrate
n/a
Meas. Tech.
ChEMBL_1338348 (CHEMBL3240084)
IC50
130±n/a nM
Citation
 Kawamura, S; Unno, Y; Asai, A; Arisawa, M; Shuto, S Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates. J Med Chem 57:2726-35 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-7
Synonyms:
Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z
Type:
PROTEIN
Mol. Mass.:
29968.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
277
Sequence:
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
  
Inhibitor
Name:
BDBM50007197
Synonyms:
CHEMBL3237869
Type:
Small organic molecule
Emp. Form.:
C45H60BN3O7
Mol. Mass.:
765.785
SMILES:
[H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(O[C@]1([H])C2)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1ccccc1 |r|
Structure:
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