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Target
Proteasome subunit beta type-7
Ligand
BDBM50069989
Substrate
n/a
Meas. Tech.
ChEMBL_1338347 (CHEMBL3240083)
IC50
7.0±n/a nM
Citation
 Kawamura, S; Unno, Y; Asai, A; Arisawa, M; Shuto, S Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates. J Med Chem 57:2726-35 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-7
Synonyms:
Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z
Type:
PROTEIN
Mol. Mass.:
29968.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
277
Sequence:
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
  
Inhibitor
Name:
BDBM50069989
Synonyms:
(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447
Type:
Small organic molecule
Emp. Form.:
C19H25BN4O4
Mol. Mass.:
384.237
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r|
Structure:
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