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TargetGlucokinase regulatory protein
LigandBDBM50009115
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1338435
IC50 28±n/a nM
Citation Nishimura, NNorman, MHLiu, LYang, KCAshton, KSBartberger, MDChmait, SChen, JCupples, RFotsch, CHelmering, JJordan, SRKunz, RKPennington, LDPoon, SFSiegmund, ASivits, GLloyd, DJHale, CSt Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J Med Chem57:3094-116 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucokinase regulatory protein
Name:Glucokinase regulatory protein
Synonyms:GCKR | GKRP | Glucokinase regulator
Type:PROTEIN
Mol. Mass.:68685.97
Organism:Homo sapiens (Human)
Description:ChEMBL_103091
Residue:625
Sequence:
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI
FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV
GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ
KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE
RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ
TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR
AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA
VRSALAGPGQKRTADPLEILEPDVQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50009115
NameBDBM50009115
Synonyms:CHEMBL3237980
TypeSmall organic molecule
Emp. Form.C21H23F3N4O4S
Mol. Mass.484.492
SMILESCC#C[C@H]1CN(CCN1c1ccc(cc1)[C@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a