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TargetNicotinamide phosphoribosyltransferase
LigandBDBM50011177
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1351812
IC50 0.632000±n/a nM
Citation  n/a ACS Med Chem Lett5:277-277 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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  Blast E-value cutoff:
BDBM50011177
NameBDBM50011177
Synonyms:CHEMBL3260315
TypeSmall organic molecule
Emp. Form.C24H27FN6O2S
Mol. Mass.482.574
SMILESFc1ccc(CN(C(=O)CN2CCC=CC2)c2ncc(s2)C(=O)NCCCn2ccnc2)cc1 |c:13|
Structure
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