Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50438936
Substrate
n/a
Meas. Tech.
ChEMBL_1351856 (CHEMBL3271362)
EC50
1.1±n/a nM
Citation
 Zheng, X; Bair, KW; Bauer, P; Baumeister, T; Bowman, KK; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Feng, Y; Han, B; Ho, YC; Kley, N; Li, H; Liang, X; Liederer, BM; Lin, J; Ly, J; O'Brien, T; Oeh, J; Oh, A; Reynolds, DJ; Sampath, D; Sharma, G; Skelton, N; Smith, CC; Tremayne, J; Wang, L; Wang, W; Wang, Z; Wu, H; Wu, J; Xiao, Y; Yang, G; Yuen, PW; Zak, M; Dragovich, PS Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett 23:5488-97 (2013) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50438936
Synonyms:
CHEMBL2420629 | GNE-617
Type:
Small organic molecule
Emp. Form.:
C21H15F2N3O3S
Mol. Mass.:
427.424
SMILES:
Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Structure:
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