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Target
Dipeptidyl peptidase 1
Ligand
BDBM50186088
Substrate
n/a
Meas. Tech.
ChEMBL_1353219 (CHEMBL3266696)
IC50
2.0±n/a nM
Citation
 Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K Cathepsin C inhibitors: property optimization and identification of a clinical candidate. J Med Chem 57:2357-67 (2014) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:
Enzyme
Mol. Mass.:
51857.28
Organism:
Homo sapiens (Human)
Description:
P53634
Residue:
463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
  
Inhibitor
Name:
BDBM50186088
Synonyms:
(S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide | (S)-2-amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramide | CHEMBL212521
Type:
Small organic molecule
Emp. Form.:
C19H21N3O
Mol. Mass.:
307.3895
SMILES:
CC[C@H](N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C#N |r|
Structure:
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