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Target
Follicle-stimulating hormone receptor
Ligand
BDBM50012103
Substrate
n/a
Meas. Tech.
ChEMBL_1351769 (CHEMBL3270558)
EC50
4900000±n/a nM
Citation
 Yu, HN; Richardson, TE; Nataraja, S; Fischer, DJ; Sriraman, V; Jiang, X; Bharathi, P; Foglesong, RJ; Haxell, TF; Heasley, BH; Jenks, M; Li, J; Dugas, MS; Collis, R; Tian, H; Palmer, S; Goutopoulos, A Discovery of substituted benzamides as follicle stimulating hormone receptor allosteric modulators. Bioorg Med Chem Lett 24:2168-72 (2014) [PubMed]  Article 
Target
Name:
Follicle-stimulating hormone receptor
Synonyms:
FSH-R | FSHR | FSHR_HUMAN | Follicle stimulating hormone receptor | Follicle-stimulating hormone receptor | Follitropin receptor | LGR1
Type:
PROTEIN
Mol. Mass.:
78273.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1351769
Residue:
695
Sequence:
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
  
Inhibitor
Name:
BDBM50012103
Synonyms:
CHEMBL3263665
Type:
Small organic molecule
Emp. Form.:
C31H38N6O3
Mol. Mass.:
542.6718
SMILES:
CN(C(=O)c1ccc[nH]1)c1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Structure:
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