Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50013041
Substrate
n/a
Meas. Tech.
ChEMBL_1351719 (CHEMBL3270119)
Ki
5141±n/a nM
Citation
 Xu, L; Zhang, Y; Zheng, L; Qiao, C; Li, Y; Li, D; Zhen, X; Hou, T Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays. J Med Chem 57:3737-45 (2014) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50013041
Synonyms:
CHEMBL3261385
Type:
Small organic molecule
Emp. Form.:
C18H14N2O5S
Mol. Mass.:
370.379
SMILES:
COc1ccc(cc1NC(=S)NC(=O)c1cc2ccccc2o1)C(O)=O
Structure:
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