Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50375373
Substrate
n/a
Meas. Tech.
ChEMBL_1349364 (CHEMBL3269587)
Ki
0.741310±n/a nM
Citation
 Wingen, K; Schwed, JS; Isensee, K; Weizel, L; Zivkovic, A; Odadzic, D; Odazic, D; Stark, H Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness. Bioorg Med Chem Lett 24:2236-9 (2014) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50375373
Synonyms:
CHEMBL129306
Type:
Small organic molecule
Emp. Form.:
C20H32N2O2
Mol. Mass.:
332.4803
SMILES:
OC1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1
Structure:
Search PDB for entries with ligand similarity: