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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50015589
Substrate
n/a
Meas. Tech.
ChEMBL_1348878 (CHEMBL3271147)
IC50
18±n/a nM
Citation
 Ovais, S; Pushpalatha, H; Reddy, GB; Rathore, P; Bashir, R; Yaseen, S; Dheyaa, A; Yaseen, R; Tanwar, O; Akthar, M; Samim, M; Javed, K Synthesis and biological evaluation of some new pyrazoline substituted benzenesulfonylurea/thiourea derivatives as anti-hyperglycaemic agents and aldose reductase inhibitors. Eur J Med Chem 80:209-17 (2014) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50015589
Synonyms:
CHEMBL3260160
Type:
Small organic molecule
Emp. Form.:
C30H35N5O2S2
Mol. Mass.:
561.761
SMILES:
CN(C)c1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccc(cc1)S(=O)(=O)NC(=S)NC1CCCCC1 |t:10|
Structure:
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