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TargetActivin receptor type-1B
LigandBDBM50015639
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1349305
IC50 13±n/a nM
Citation Jin, CHKrishnaiah, MSreenu, DSubrahmanyam, VBRao, KSLee, HJPark, SJPark, HJLee, KSheen, YYKim, DK Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF- type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. J Med Chem57:4213-38 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Activin receptor type-1B
Name:Activin receptor type-1B
Synonyms:ACVR1B
Type:PROTEIN
Mol. Mass.:56810.99
Organism:Homo sapiens
Description:ChEMBL_587064
Residue:505
Sequence:
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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  Blast E-value cutoff:
BDBM50015639
NameBDBM50015639
Synonyms:CHEMBL3260567
TypeSmall organic molecule
Emp. Form.C22H18FN7
Mol. Mass.399.4236
SMILESCc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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