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Target
NAD-dependent protein deacylase sirtuin-6
Ligand
BDBM50017341
Substrate
n/a
Meas. Tech.
ChEMBL_1362800 (CHEMBL3295497)
IC50
106000±n/a nM
Citation
 Parenti, MD; Grozio, A; Bauer, I; Galeno, L; Damonte, P; Millo, E; Sociali, G; Franceschi, C; Ballestrero, A; Bruzzone, S; Del Rio, A; Nencioni, A Discovery of novel and selective SIRT6 inhibitors. J Med Chem 57:4796-804 (2014) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-6
Synonyms:
NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6)
Type:
Protein
Mol. Mass.:
39133.03
Organism:
Homo sapiens (Human)
Description:
Q8N6T7
Residue:
355
Sequence:
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
  
Inhibitor
Name:
BDBM50017341
Synonyms:
CHEMBL3288034
Type:
Small organic molecule
Emp. Form.:
C19H14N4O5S
Mol. Mass.:
410.403
SMILES:
O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Structure:
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