Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50445062
Substrate
n/a
Meas. Tech.
ChEMBL_1365631 (CHEMBL3297478)
EC50
400±n/a nM
Citation
 Atigadda, VR; Xia, G; Desphande, A; Boerma, LJ; Lobo-Ruppert, S; Grubbs, CJ; Smith, CD; Brouillette, WJ; Muccio, DD Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J Med Chem 57:5370-80 (2014) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B Channel Blocker | Nr2b1 | RXRA_RAT | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha | Rxra
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51273.78
Organism:
RAT
Description:
NR2B Channel Blocker 0 RAT::Q05343
Residue:
467
Sequence:
MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFETGSPQLNSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT
  
Inhibitor
Name:
BDBM50445062
Synonyms:
CHEMBL3098771
Type:
Small organic molecule
Emp. Form.:
C20H22O2
Mol. Mass.:
294.3875
SMILES:
C/C(/C=C/C=C(/C)\C=C1/CCCc2ccccc12)=C\C(O)=O
Structure:
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