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Target
Beta-glucuronidase
Ligand
BDBM50019277
Substrate
n/a
Meas. Tech.
ChEMBL_1362174 (CHEMBL3295183)
IC50
3200±n/a nM
Citation
 Khan, KM; Saad, SM; Shaikh, NN; Hussain, S; Fakhri, MI; Perveen, S; Taha, M; Choudhary, MI Synthesis andß-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones. Bioorg Med Chem 22:3449-54 (2014) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase)
Type:
Protein
Mol. Mass.:
74736.05
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
651
Sequence:
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
  
Inhibitor
Name:
BDBM50019277
Synonyms:
2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-one (6) | CHEMBL3289119
Type:
Small organic molecule
Emp. Form.:
C14H10N2O3
Mol. Mass.:
254.2408
SMILES:
Oc1ccc(O)c(c1)-c1nc2ccccc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: