Reaction Details Report a problem with these data
Target
Neurotensin receptor type 2
Ligand
BDBM50019410
Substrate
n/a
Meas. Tech.
ChEMBL_1364514 (CHEMBL3295311)
EC50
94±n/a nM
Citation
 Thomas, JB; Giddings, AM; Wiethe, RW; Olepu, S; Warner, KR; Sarret, P; Gendron, L; Longpre, JM; Zhang, Y; Runyon, SP; Gilmour, BP Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J Med Chem 57:5318-32 (2014) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 2
Synonyms:
High-affinity levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2_RAT | Neurotensin receptor 2 | Neurotensin receptor type 2 | Ntr2 | Ntsr2
Type:
PROTEIN
Mol. Mass.:
46280.50
Organism:
Rattus norvegicus
Description:
ChEMBL_1466615
Residue:
416
Sequence:
METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
  
Inhibitor
Name:
BDBM50019410
Synonyms:
CHEMBL3290094
Type:
Small organic molecule
Emp. Form.:
C31H33ClN4O5
Mol. Mass.:
577.071
SMILES:
CCc1c(nn(c1-c1c(OC)cccc1OC)-c1ccnc2cc(Cl)ccc12)C(=O)N[C@@H](C1CCCCC1)C(O)=O |r,wU:31.35,(24.97,-8.62,;24.81,-10.16,;23.41,-10.78,;22.07,-10.01,;20.93,-11.04,;21.56,-12.45,;23.09,-12.29,;24.43,-13.78,;23.95,-15.24,;22.44,-15.56,;21.97,-17.03,;24.98,-16.39,;26.49,-16.06,;26.96,-14.6,;25.93,-13.46,;26.41,-11.99,;27.91,-11.67,;20.55,-14.18,;21.32,-15.52,;20.55,-16.85,;19.01,-16.85,;18.24,-15.52,;16.7,-15.52,;15.93,-14.18,;14.39,-14.18,;16.7,-12.85,;18.24,-12.85,;19.01,-14.18,;21.91,-8.48,;23.16,-7.58,;20.51,-7.85,;20.34,-6.32,;18.94,-5.7,;17.69,-6.6,;16.28,-5.97,;16.12,-4.44,;17.37,-3.54,;18.78,-4.16,;21.59,-5.42,;21.43,-3.89,;23,-6.04,)|
Structure:
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