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Target
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Ligand
BDBM50020310
Substrate
n/a
Meas. Tech.
ChEMBL_1365414 (CHEMBL3296773)
Ki
840±n/a nM
Citation
 Zhang, L; Zheng, Q; Yang, Y; Zhou, H; Gong, X; Zhao, S; Fan, C Synthesis and in vivo SAR study of indolin-2-one-based multi-targeted inhibitors as potential anticancer agents. Eur J Med Chem 82:139-51 (2014) [PubMed]  Article 
Target
Name:
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Synonyms:
PHKG2 | PHKG2_HUMAN | Phosphorylase kinase | Phosphorylase kinase gamma subunit 2
Type:
PROTEIN
Mol. Mass.:
46440.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774277
Residue:
406
Sequence:
MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
  
Inhibitor
Name:
BDBM50020310
Synonyms:
CHEMBL3288854
Type:
Small organic molecule
Emp. Form.:
C23H28FN5O2
Mol. Mass.:
425.4991
SMILES:
CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Structure:
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