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Target
Nuclear factor erythroid 2-related factor 2
Ligand
BDBM50067028
Substrate
n/a
Meas. Tech.
ChEMBL_1361574 (CHEMBL3295141)
EC50
900±n/a nM
Citation
 Koeberle, A; Muņoz, E; Appendino, GB; Minassi, A; Pace, S; Rossi, A; Weinigel, C; Barz, D; Sautebin, L; Caprioglio, D; Collado, JA; Werz, O SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. J Med Chem 57:5638-48 (2014) [PubMed]  Article 
Target
Name:
Nuclear factor erythroid 2-related factor 2
Synonyms:
HEBP1 | Kelch-like ECH-associated protein 1 | NF-E2-related factor 2 | NF2L2_HUMAN | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2
Type:
PROTEIN
Mol. Mass.:
67786.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107924
Residue:
605
Sequence:
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN
  
Inhibitor
Name:
BDBM50067028
Synonyms:
(1E,4E)-1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one | (1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one | 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one | 1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one | 1,5-bis-(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one | CHEMBL128729 | Go-Y022
Type:
Small organic molecule
Emp. Form.:
C19H18O5
Mol. Mass.:
326.3432
SMILES:
COc1cc(\C=C\C(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
Structure:
Search PDB for entries with ligand similarity: