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Target
Proteasome subunit beta type-1
Ligand
BDBM50021351
Substrate
n/a
Meas. Tech.
ChEMBL_1366691 (CHEMBL3296842)
Ki
1250±n/a nM
Citation
 Troiano, V; Scarbaci, K; Ettari, R; Micale, N; Cerchia, C; Pinto, A; Schirmeister, T; Novellino, E; Grasso, S; Lavecchia, A; Zappalą, M Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors. Eur J Med Chem 83:1-14 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50021351
Synonyms:
CHEMBL3287942
Type:
Small organic molecule
Emp. Form.:
C19H27BN2O6
Mol. Mass.:
390.238
SMILES:
COc1cc2ccn(CCC(=O)N[C@@H](CC(C)C)B(O)O)c(=O)c2cc1OC |r|
Structure:
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