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Target
D(2) dopamine receptor
Ligand
BDBM50021770
Substrate
n/a
Meas. Tech.
ChEMBL_1369055 (CHEMBL3300168)
EC50
0.300000±n/a nM
Citation
 Szabo, M; Klein Herenbrink, C; Christopoulos, A; Lane, JR; Capuano, B Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor. J Med Chem 57:4924-39 (2014) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50021770
Synonyms:
CHEMBL3298895
Type:
Small organic molecule
Emp. Form.:
C25H31Cl2N5OS
Mol. Mass.:
520.518
SMILES:
Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Structure:
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