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Target
D(2) dopamine receptor
Ligand
BDBM50001862
Substrate
n/a
Meas. Tech.
ChEMBL_1369051 (CHEMBL3300164)
IC50
>1000±n/a nM
Citation
 Szabo, M; Klein Herenbrink, C; Christopoulos, A; Lane, JR; Capuano, B Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor. J Med Chem 57:4924-39 (2014) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50001862
Synonyms:
(N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl)-piperazine | 1-(2-Methoxy-phenyl)-piperazine | 2-METHOXYPHENYLPIPERAZINE | 4-(2-Methoxy-phenyl)-piperazin-1-ium | CHEMBL9666 | EN300-33366
Type:
Small organic molecule
Emp. Form.:
C11H16N2O
Mol. Mass.:
192.2575
SMILES:
COc1ccccc1N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: