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Target
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Ligand
BDBM50023350
Substrate
n/a
Meas. Tech.
ChEMBL_1459634 (CHEMBL3369891)
Ki
45±n/a nM
Citation
 Ferla, S; Aboraia, AS; Brancale, A; Pepper, CJ; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. J Med Chem 57:7702-15 (2014) [PubMed]  Article 
Target
Name:
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Synonyms:
25-OHD-1 alpha-hydroxylase | 25-hydroxyvitamin D(3) 1-alpha-hydroxylase | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_MOUSE | Calcidiol 1-monooxygenase | Cyp27b | Cyp27b | Cyp27b1 | Cyp40 | Cytochrome P450 subfamily XXVIIB polypeptide 1 | Cytochrome P450C1 alpha | Cytochrome P450VD1-alpha | Cytochrome p450 27B1 | VD3 1A hydroxylase
Type:
PROTEIN
Mol. Mass.:
56238.51
Organism:
Mus musculus
Description:
ChEMBL_109473
Residue:
507
Sequence:
MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERSINLQFVDR
  
Inhibitor
Name:
BDBM50023350
Synonyms:
CHEMBL3329771
Type:
Small organic molecule
Emp. Form.:
C26H24FN3O
Mol. Mass.:
413.4867
SMILES:
Fc1ccc(CCc2ccc(cc2)C(=O)NCC(c2ccccc2)n2ccnc2)cc1
Structure:
Search PDB for entries with ligand similarity: