Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50023376
Substrate
n/a
Meas. Tech.
ChEMBL_1460447 (CHEMBL3367331)
Ki
0.199526±n/a nM
Citation
 Brudeli, B; Navaratnarajah, M; Andressen, KW; Manfra, O; Moltzau, LR; Nilsen, NO; Levy, FO; Klaveness, J Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists. Bioorg Med Chem Lett 24:4598-602 (2014) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4
Type:
Enzyme
Mol. Mass.:
43767.54
Organism:
Homo sapiens (Human)
Description:
Q13639
Residue:
388
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
  
Inhibitor
Name:
BDBM50023376
Synonyms:
CHEMBL3329806
Type:
Small organic molecule
Emp. Form.:
C31H40N4O4S
Mol. Mass.:
564.739
SMILES:
O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c2OCCCn2c2ccccc12
Structure:
Search PDB for entries with ligand similarity: