Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50025625
Substrate
n/a
Meas. Tech.
ChEMBL_1431198 (CHEMBL3385061)
Ki
114±n/a nM
Citation
 Alafeefy, AM; Ceruso, M; Al-Tamimi, AM; Del Prete, S; Capasso, C; Supuran, CT Quinazoline-sulfonamides with potent inhibitory activity against thea-carbonic anhydrase from Vibrio cholerae. Bioorg Med Chem 22:5133-40 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50025625
Synonyms:
CHEMBL3337995
Type:
Small organic molecule
Emp. Form.:
C24H22N4O3S3
Mol. Mass.:
510.651
SMILES:
Cc1cccc2c1nc(SCC(=O)Nc1ccc(cc1)S(N)(=O)=O)n(Cc1ccccc1)c2=S
Structure:
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