Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50025825
Substrate
n/a
Meas. Tech.
ChEMBL_1436698 (CHEMBL3384774)
EC50
41400±n/a nM
Citation
 Hinklin, RJ; Aicher, TD; Anderson, DA; Baer, BR; Boyd, SA; Condroski, KR; DeWolf, WE; Kraser, CF; McVean, M; Rhodes, SP; Sturgis, HL; Voegtli, WC; Williams, L; Houze, JB Discovery of 2-pyridylureas as glucokinase activators. J Med Chem 57:8180-6 (2014) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50025825
Synonyms:
CHEMBL3338056
Type:
Small organic molecule
Emp. Form.:
C18H16N4O2S
Mol. Mass.:
352.41
SMILES:
CCc1ncccc1Oc1cc(Sc2ccccn2)cnc1NC=O
Structure:
Search PDB for entries with ligand similarity: