Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50026240
Substrate
n/a
Meas. Tech.
ChEMBL_1438933 (CHEMBL3382444)
EC50
14±n/a nM
Citation
 Wacker, DAWang, YBroekema, MRossi, KO'Connor, SHong, ZWu, GMalmstrom, SEHung, CPLaMarre, LChimalakonda, AZhang, LXin, LCai, HChu, CBoehm, SZalaznick, JPonticiello, RSereda, LHan, SPZebo, RZinker, BLuk, CEWong, REverlof, GLi, YXWu, CKLee, MGriffen, SMiller, KJKrupinski, JRobl, JA Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119. J Med Chem 57:7499-508 (2014) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50026240
Synonyms:
CHEMBL3338194
Type:
Small organic molecule
Emp. Form.:
C21H19Cl2FN4O4S
Mol. Mass.:
513.369
SMILES:
CS(=O)(=O)c1ccc(c(F)c1)-n1cc(Cl)c(OC2CCN(CC2)c2ncc(Cl)cn2)cc1=O
Structure:
Search PDB for entries with ligand similarity: