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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM50029052
Substrate
n/a
Meas. Tech.
ChEMBL_1435499 (CHEMBL3385319)
Ki
>10000±n/a nM
Citation
 Yoshida, Y; Terauchi, T; Naoe, Y; Kazuta, Y; Ozaki, F; Beuckmann, CT; Nakagawa, M; Suzuki, M; Kushida, I; Takenaka, O; Ueno, T; Yonaga, M Design, synthesis, and structure-activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists. Bioorg Med Chem 22:6071-88 (2014) [PubMed]  Article 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM50029052
Synonyms:
CHEMBL3343248
Type:
Small organic molecule
Emp. Form.:
C24H24N2O4
Mol. Mass.:
404.4584
SMILES:
COc1ccc(cc1OC)[C@]1(COc2ccccc2)C[C@H]1C(=O)Nc1ccccn1 |r|
Structure:
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