Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50029924
Substrate
n/a
Meas. Tech.
ChEMBL_1438384 (CHEMBL3383059)
IC50
210±n/a nM
Citation
 Lucchesi, V; Hurst, DP; Shore, DM; Bertini, S; Ehrmann, BM; Allarà, M; Lawrence, L; Ligresti, A; Minutolo, F; Saccomanni, G; Sharir, H; Macchia, M; Di Marzo, V; Abood, ME; Reggio, PH; Manera, C CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem 57:8777-91 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50029924
Synonyms:
CHEMBL3353427
Type:
Small organic molecule
Emp. Form.:
C20H27N3O3
Mol. Mass.:
357.4467
SMILES:
CC1CCC(CC1)NC(=O)c1cc2cccnc2n(CCCCO)c1=O |(22.97,-9.81,;21.64,-10.59,;21.64,-12.13,;20.31,-12.9,;18.97,-12.13,;18.96,-10.6,;20.3,-9.82,;17.64,-12.91,;16.3,-12.14,;16.3,-10.6,;14.98,-12.92,;13.64,-12.16,;12.31,-12.94,;10.98,-12.17,;9.65,-12.94,;9.65,-14.49,;10.98,-15.26,;12.31,-14.48,;13.65,-15.25,;13.65,-16.79,;14.99,-17.55,;16.32,-16.78,;17.66,-17.55,;18.99,-16.77,;14.98,-14.47,;16.32,-15.24,)|
Structure:
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