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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50030149
Substrate
n/a
Meas. Tech.
ChEMBL_1438398 (CHEMBL3383627)
IC50
30100±n/a nM
Citation
 Cui, H; Kamal, Z; Ai, T; Xu, Y; More, SS; Wilson, DJ; Chen, L Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach. J Med Chem 57:8340-57 (2014) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50030149
Synonyms:
CHEMBL3343531
Type:
Small organic molecule
Emp. Form.:
C16H12N2OS
Mol. Mass.:
280.344
SMILES:
NC(=O)c1cncc(Sc2cccc3ccccc23)c1
Structure:
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