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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50030103
Substrate
n/a
Meas. Tech.
ChEMBL_1438398 (CHEMBL3383627)
IC50
19300±n/a nM
Citation
 Cui, H; Kamal, Z; Ai, T; Xu, Y; More, SS; Wilson, DJ; Chen, L Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach. J Med Chem 57:8340-57 (2014) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50030103
Synonyms:
CHEMBL3343654
Type:
Small organic molecule
Emp. Form.:
C23H16N4O5
Mol. Mass.:
428.3969
SMILES:
NC(=O)c1cncc(Oc2cccc3c(NC(=O)c4cccc(c4)[N+]([O-])=O)cccc23)c1
Structure:
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