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Target
Cathepsin S
Ligand
BDBM50030817
Substrate
n/a
Meas. Tech.
ChEMBL_1438542 (CHEMBL3385532)
IC50
2780±n/a nM
Citation
 Jadhav, PK; Schiffler, MA; Gavardinas, K; Kim, EJ; Matthews, DP; Staszak, MA; Coffey, DS; Shaw, BW; Cassidy, KC; Brier, RA; Zhang, Y; Christie, RM; Matter, WF; Qing, K; Durbin, JD; Wang, Y; Deng, GG Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett 5:1138-42 (2014) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_MOUSE | Cats | Ctss
Type:
Enzyme
Mol. Mass.:
38476.67
Organism:
Mus musculus (Mouse)
Description:
O70370
Residue:
340
Sequence:
MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
  
Inhibitor
Name:
BDBM50030817
Synonyms:
CHEMBL3342551
Type:
Small organic molecule
Emp. Form.:
C23H28N4O2
Mol. Mass.:
392.494
SMILES:
CN1CCN(CC1)C(=O)Nc1ccc2CCCC(NC(=O)c3ccccc3)c2c1
Structure:
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