Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50029215
Substrate
n/a
Meas. Tech.
ChEMBL_1441631 (CHEMBL3377077)
EC50
11000±n/a nM
Citation
 Yokoyama, T; Kosaka, Y; Mizuguchi, M Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin. J Med Chem 57:8928-35 (2014) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50029215
Synonyms:
(E)-3-(3-Hydroxy-4-methoxy-phenyl)-acrylic acid phenethyl ester | 3-(3-Hydroxy-4-methoxy-phenyl)-acrylic acid phenethyl ester | CHEMBL131680
Type:
Small organic molecule
Emp. Form.:
C18H18O4
Mol. Mass.:
298.3331
SMILES:
COc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O
Structure:
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