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Target
Sodium-dependent neutral amino acid transporter B(0)AT2
Ligand
BDBM50036935
Substrate
n/a
Meas. Tech.
ChEMBL_1432515 (CHEMBL3386947)
IC50
>40000±n/a nM
Citation
 Cuboni, S; Devigny, C; Hoogeland, B; Strasser, A; Pomplun, S; Hauger, B; Höfner, G; Wanner, KT; Eder, M; Buschauer, A; Holsboer, F; Hausch, F Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. J Med Chem 57:9473-9 (2014) [PubMed]  Article 
Target
Name:
Sodium-dependent neutral amino acid transporter B(0)AT2
Synonyms:
B0AT2 | B0AT2 | NTT73 | S6A15_HUMAN | SBAT1 | SLC6A15 | Sodium- and chloride-dependent neurotransmitter transporter NTT73 | Sodium-coupled branched-chain amino-acid transporter 1 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Solute carrier family 6 member 15 | Transporter v7-3
Type:
PROTEIN
Mol. Mass.:
81820.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109513
Residue:
730
Sequence:
MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADIMPDMPESDL
  
Inhibitor
Name:
BDBM50036935
Synonyms:
8-Chloro-11-[1-(5-methyl-pyridin-3-ylmethyl)-piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | CHEMBL91397 | Rupatadine
Type:
Small organic molecule
Emp. Form.:
C26H26ClN3
Mol. Mass.:
415.958
SMILES:
[#6]-c1cncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2\c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)c1
Structure:
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