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Target
Free fatty acid receptor 2
Ligand
BDBM50032375
Substrate
n/a
Meas. Tech.
ChEMBL_1440135 (CHEMBL3382548)
IC50
57±n/a nM
Citation
 Pizzonero, M; Dupont, S; Babel, M; Beaumont, S; Bienvenu, N; Blanqué, R; Cherel, L; Christophe, T; Crescenzi, B; De Lemos, E; Delerive, P; Deprez, P; De Vos, S; Djata, F; Fletcher, S; Kopiejewski, S; L'Ebraly, C; Lefrançois, JM; Lavazais, S; Manioc, M; Nelles, L; Oste, L; Polancec, D; Quénéhen, V; Soulas, F; Triballeau, N; van der Aar, EM; Vandeghinste, N; Wakselman, E; Brys, R; Saniere, L Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem 57:10044-57 (2014) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM50032375
Synonyms:
CHEMBL3353530
Type:
Small organic molecule
Emp. Form.:
C27H27F3N2O4S
Mol. Mass.:
532.574
SMILES:
CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc(cc1)C(F)(F)F
Structure:
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